|
週次 |
日期 |
單元主題 |
|
第1週 |
9/11 |
迎新學術研討會，停課一次 |
|
第2週 |
9/18 |
A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220. Cancer Research(2017), 77(16):4402(傅宇暄)
The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells. Blood Cancer Journal . 2017 Feb; 7(2): e527 (羅芳妤) |
|
第3週 |
9/25 |
Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development(黃焱)
MicroRNA-206 acts as a tumor suppressor in bladder cancer via targeting YRDC. American Journal of Translational Research, 2016; 8(11):4705-4715(高亦欣) |
|
第4週 |
10/02 |
Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy.
Blood 2016 128:253-264(呂文惠)
Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential. Cancer Cell. 2016 Nov 14;30(5):779-791(吳潔雯)
|
|
第5週 |
10/09 |
調整放假 |
|
第6週 |
10/16 |
A Bak-dependent mitochondrial amplification step contributes to Smac mimetic /glucocorticoid-induced necroptosis
Cell Death and Differentiation 2017;24:83–97(周映辰)
LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis
Cancer Cell 2017; 32: 310–323(王克巍)
|
|
第7週 |
10/23 |
The role of ZAP70 kinase in acute
lymphoblastic leukemia infiltration into the central nervous system.(陳怡臻)
The Role of the Gastrointestinal Microbiome in Infectious Complications During Induction Chemotherapy for Acute Myeloid Leukemia(劉育安) |
|
第8週 |
10/30 |
Genetic deletion or small-molecule inhibition of the arginine methyltransferase PRMT5 exhibit anti-tumoral activity in mouse models of MLL-rearranged AML(羅芳妤)
Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion. (傅宇暄)
|
|
第9週 |
11/06 |
Oncogenic FLT3-ITD supports autophagy via ATF4 in acute myeloid leukemia.(呂文惠)
High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells. (吳潔雯)
|
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第10週 |
11/13 |
A non-coding function of TYRP1 mRNA promotes melanoma growth. (高亦欣)
The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis. (陳怡臻)
|
|
第11週 |
11/20 |
Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia. (周映辰)
Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression.(王克巍)
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